Semaglutide Microdosing Program
Learn about our medically managed, 12-week comprehensive program with semaglutide (GLP-1). This program is recommended for anyone who has optimized hormones, nutrients, and lifestyle, but still needs anti-inflammatory or modest body composition changes.
What is microdosing?
Microdosing is using 1/5 to 1/10 of a low dose of semaglutide GLP-1 to achieve various benefits, while reducing side effects.
Many of us are frustrated because we have changed our lifestyle, optimized our hormones and taken the right supplements. When we keep trying things that used to work and see no results, we can feel defeated and often give up.
Our friends, family and even our doctors may tell us “This is just the way it is,” but the truth is that YOU CAN meet your goals and improve your longevity and quality of life.
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Benefits May Include
1. Reduced Inflammation: Chronic low-grade inflammation is often the root of many metabolic diseases, including heart disease, obesity, and type 2 diabetes. Studies suggest that GLP-1 receptor agonists may have anti-inflammatory effects, reducing markers of inflammation throughout the body. By decreasing inflammation, micro-doses of semaglutide may help improve heart health, reduce joint pain, and even support better immune function.
2. Improved Blood Sugar Control Originally developed to manage blood sugar in individuals with type 2 diabetes, semaglutide mimics a hormone called glucagon-like peptide-1 (GLP-1) that regulates blood sugar by enhancing insulin release and decreasing glucagon secretion. Micro-dosing can provide gentle but effective improvements in blood sugar stability, even for those who are not diabetic. Studies show that better blood sugar management can lead to improved energy, reduced sugar cravings, and a lower risk of developing prediabetes, many diseases and slow inflammation-related aging.
3. Enhanced Insulin Sensitivity Micro-dosing semaglutide also aids in enhancing insulin sensitivity, making the body more efficient at processing glucose. Research shows that even in small amounts, these medications help improve cellular responses to insulin, which is essential for metabolic health. Enhanced insulin sensitivity can reduce the risk of metabolic syndrome—a combination of high blood pressure, high blood sugar, and abnormal cholesterol levels that increases the risk of heart disease. It can also improve muscle mass.
4. Cardiovascular Protection Research has found that even at lower doses, GLP-1 agonists help lower blood pressure, improve lipid profiles by reducing LDL cholesterol and triglycerides, and reduce the risk of cardiovascular events. This heart-protective effect makes these drugs valuable beyond weight loss, supporting long-term cardiovascular health.
5. Support for Liver Health Non-alcoholic fatty liver disease (NAFLD) is a growing concern in metabolic health, often associated with insulin resistance and obesity. GLP-1 receptor agonists have shown promise in reducing liver fat content, which is essential for individuals at risk for NAFLD. Even in micro-doses, these drugs support liver health by enhancing fat metabolism and decreasing fatty acid buildup in the liver, helping to prevent further liver-related complications.
6. Appetite Regulation and Improved Satiety One of the unique benefits of GLP-1 receptor agonists is their ability to promote feelings of fullness and reduce appetite. However, the advantage of micro-dosing is that it can subtly impact hunger signals without causing drastic changes in appetite, which can be helpful for those seeking to maintain their current weight or avoid rapid weight fluctuations. This improved satiety can support a balanced approach to food intake, reducing overeating and promoting a healthier relationship with food.

7. Hormonal Balance GLP-1 agonists also influence hormone levels beyond insulin. Some studies indicate that these medications may positively impact hormones related to energy regulation and metabolic function. Micro-dosing may gently support these hormonal changes, contributing to overall metabolic stability and reducing the fluctuations that can lead to cravings, fatigue, and energy dips.
8. Cognitive Benefits Emerging research suggests that GLP-1 receptor agonists may help protect against cognitive decline by reducing brain inflammation and improving blood flow to the brain. Micro-dosing offers a way to potentially harness these neuroprotective benefits over time, which can be beneficial for mental clarity, memory, and focus.
9. Substances Many patients have decrease cravings for alcohol, tobacco, etc., due to the increase in the satiety centers of the brain.
10. Modest change in body composition Because of the effects listed above, some patient may experience a modest amount of fat loss and even muscle gain. If more than 10 pounds of weight reduction is the primary goal, you want to consider our bespoke weight optimization program, which can be started at very low doses.


Who is NOT a candidate?
Individuals with severe inflammatory bowel disease (IBD), gastroparesis (nerve damage to the gut), or a personal or family history of multiple endocrine neoplasia type 2A or 2B, medullary thyroid cancer, or pancreatitis should not take GLP-1’s.
What To Expect On Your Three-Month Journey
Step 1: When necessary a pre-visit lab draw, (may be run through your insurance) to assess hormones and general wellness, including diabetes and lipid screening. If you are a new patient and you have not previously had a dedicated hormone optimization consult, we will schedule that first (prior to scheduling your first consultation) since hormone balance is foundational to success. Based on your personal needs, we will recommend the latest and safest hormonal support and supplements to help you to succeed and offer nutrition and movement advice that will work with your lifestyle.
Step 2: Initial 30-minute consultation with a nurse practitioner to evaluate your body composition, goals and plan. We will teach you to inject the medication and give you a vial for weekly use at home.
Step 3: 30-minute virtual or in-person check in every four weeks for 3 visits – includes body composition, review of nutrition, movement, medications and supplements.
Step 4: If your journey continues past 12 weeks, 30-minute check in every four-weeks as needed until we reach your goal.
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Currently, evidence for microdosing is observational and emerging. There is 1 trial underway that is actively studying the effectiveness of microdosed GLP‑1 receptor agonists for improving health and quality of life. ClinicalTrials.gov (NCT07092605, July 30, 2025)
Here are a few trials that support use of GLP-1’s for other than diabetes and weight loss. The doses used were standard doses.
- Cognitive-Wang 2024, Gejl 2016, Athauda 2017
- Inflammation-Ren 2025, Mason 2024
- Liver-Arun 2025, Newsome 2021
- Cardiovascular and kidney-LEADER, Sustain-6, REWIND, SELECT, FLOW
